Case-cohort design in practice – experiences from the MORGAM Project
Open Access
- 4 December 2007
- journal article
- Published by Springer Science and Business Media LLC in Epidemiologic Perspectives & Innovations
- Vol. 4 (1), 15
- https://doi.org/10.1186/1742-5573-4-15
Abstract
When carefully planned and analysed, the case-cohort design is a powerful choice for follow-up studies with multiple event types of interest. While the literature is rich with analysis methods for case-cohort data, little is written about the designing of a case-cohort study. Our experiences in designing, coordinating and analysing the MORGAM case-cohort study are potentially useful for other studies with similar characteristics. The motivation for using the case-cohort design in the MORGAM genetic study is discussed and issues relevant to its planning and analysis are studied. We propose solutions for appending the earlier case-cohort selection after an extension of the follow-up period and for achieving maximum overlap between earlier designs and the case-cohort design. Approaches for statistical analysis are studied in a simulation example based on the MORGAM data.Keywords
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