Label-Free Biosensors Based on Aptamer-Modified Graphene Field-Effect Transistors
Top Cited Papers
- 3 December 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 132 (51), 18012-18013
- https://doi.org/10.1021/ja108127r
Abstract
A label-free immunosensor based on an aptamer-modified graphene field-effect transistor (G-FET) is demonstrated. Immunoglobulin E (IgE) aptamers with an approximate height of 3 nm were successfully immobilized on a graphene surface, as confirmed by atomic force microscopy. The aptamer-modified G-FET showed selective electrical detection of IgE protein. From the dependence of the drain current variation on the IgE concentration, the dissociation constant was estimated to be 47 nM, indicating good affinity and the potential for G-FETs to be used in biological sensors.This publication has 26 references indexed in Scilit:
- Carbon Nanomaterials in Biosensors: Should You Use Nanotubes or Graphene?Angewandte Chemie, 2010
- Glucose biosensor based on immobilization of glucose oxidase in platinum nanoparticles/graphene/chitosan nanocomposite filmTalanta, 2009
- Graphene-like nano-sheets for surface acoustic wave gas sensor applicationsChemical Physics Letters, 2009
- Catalyst‐Free Efficient Growth, Orientation and Biosensing Properties of Multilayer Graphene Nanoflake Films with Sharp Edge PlanesAdvanced Functional Materials, 2008
- Reduced Graphene Oxide Molecular SensorsNano Letters, 2008
- Trace gas detection using nanostructured graphite layersApplied Physics Letters, 2007
- Simple Fabrication of a Highly Sensitive Glucose Biosensor Using Enzymes Immobilized in Exfoliated Graphite Nanoplatelets Nafion MembraneChemistry of Materials, 2007
- Detection of individual gas molecules adsorbed on grapheneNature Materials, 2007
- The rise of grapheneNature Materials, 2007
- Electric Field Effect in Atomically Thin Carbon FilmsScience, 2004