Effects of spontaneous breathing during airway pressure release ventilation on renal perfusion and function in patients with acute lung injury

Abstract

Objective. Controlled mechanical ventilation can impair systemic and renal blood flow and function, which may be aggravated by respiratory acidosis. We hypothesized that partial ventilatory support using airway pressure release ventilation (APRV) with spontaneous breathing provides better cardiopulmonary and renal function than full ventilatory support using APRV without spontaneous breathing. Design. Prospective randomized study. Setting. Intensive care unit of a university hospital. Patients. Twelve patients with acute lung injury (ALI). Interventions. Airway pressure release ventilation with and without spontaneous breathing, maintaining either the same minute ventilation (V_E) or the same airway pressure (Paw) limits. Measurements. Systemic hemodynamics were estimated by double-indicator dilution, effective renal blood flow (ERBF) by para-aminohippurate, and glomerular filtration rate (GFR) by inulin clearance. Results. Compared to APRV with spontaneous breathing, cardiac index (CI) was decreased when the upper Paw limit was increased to provide the same V_E (4.26±1.21 l min^–1 m^–2 vs 3.72±0.99 l min^–1 m^–2; p–1 m^–2; p–1 m^–2 and 94±47 ml min^–1 m^–2) than during APRV without spontaneous breathing and the same V_E (714±236 ml min^–1 m^–2 and 82±35 ml min^–1 m^–2) or the same Paw (675±287 ml min^–1 m^–2 and 80±41 ml min^–1 m^–2 ;pConclusions. Spontaneous breathing during APRV was associated with better renal perfusion and function than APRV without spontaneous breathing applying either the same V_E or the same Paw limits. Maintaining spontaneous breathing during ventilatory support may, therefore, be advantageous in preventing deterioration of renal function in patients with ALI.