IgA-dependent, monocyte-mediated, antibacterial activity.
Open Access
- 1 August 1980
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 152 (2), 452-457
- https://doi.org/10.1084/jem.152.2.452
Abstract
IgA purified from the sera of patients convalescing from disseminated group C meningococcal disease induced human monocyte-mediated anti-meningococcal activity in vitro in the absence of complement. Both IgA- and IgG-dependent activity were directed against the group C meningococcal polysaccharide (Csss) capsule. The amount of IgA that was effective bound less than 1 ng of Csss. Antibacterial activity was dependent upon the length and the temperature of the test incubation and on the concentration of monocytes. The implications of this mechanism for local cell-mediated antibacterial immunity are discussed.This publication has 22 references indexed in Scilit:
- Antibody-dependent Mononuclear Cell-mediated Antimeningococcal ActivityJCI Insight, 1980
- Antibody-Dependent Cell-Mediated Antibacterial Activity of Human Mononuclear Cells. II. Immune Specificity of Antimeningococcal ActivityThe Journal of Infectious Diseases, 1980
- Antibody-dependent cell-mediated antibacterial activity of human mononuclear cells. I. K lymphocytes and monocytes are effective against meningococi in cooperation with human imune sera.The Journal of Experimental Medicine, 1979
- Specificity of opsonic antibodies to enhance phagocytosis of Pseudomonas aeruginosa by human alveolar macrophages.JCI Insight, 1975
- Phagocytic and Bactericidal Properties of Normal Human MonocytesJCI Insight, 1974
- THE RELATIONSHIP BETWEEN GROUP A AND GROUP C MENINGOCOCCAL POLYSACCHARIDES AND SERUM OPSONINS IN MANThe Journal of Experimental Medicine, 1970
- HUMAN IMMUNITY TO THE MENINGOCOCCUSThe Journal of Experimental Medicine, 1969
- HUMAN IMMUNITY TO THE MENINGOCOCCUSThe Journal of Experimental Medicine, 1969
- HUMAN IMMUNITY TO THE MENINGOCOCCUSThe Journal of Experimental Medicine, 1969
- PHAGOCYTOSIS IN SUBACUTE BACTERIAL ENDOCARDITISThe Journal of Experimental Medicine, 1968