Lipoprotein(a) in Cardiovascular Diseases
Open Access
- 30 December 2012
- journal article
- review article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2013, 1-9
- https://doi.org/10.1155/2013/650989
Abstract
Lipoprotein(a) (Lp(a)) is an LDL-like molecule consisting of an apolipoprotein B-100 (apo(B-100)) particle attached by a disulphide bridge to apo(a). Many observations have pointed out that Lp(a) levels may be a risk factor for cardiovascular diseases. Lp(a) inhibits the activation of transforming growth factor (TGF) and contributes to the growth of arterial atherosclerotic lesions by promoting the proliferation of vascular smooth muscle cells and the migration of smooth muscle cells to endothelial cells. Moreover Lp(a) inhibits plasminogen binding to the surfaces of endothelial cells and decreases the activity of fibrin-dependent tissue-type plasminogen activator. Lp(a) may act as a proinflammatory mediator that augments the lesion formation in atherosclerotic plaques. Elevated serum Lp(a) is an independent predictor of coronary artery disease and myocardial infarction. Furthermore, Lp(a) levels should be a marker of restenosis after percutaneous transluminal coronary angioplasty, saphenous vein bypass graft atherosclerosis, and accelerated coronary atherosclerosis of cardiac transplantation. Finally, the possibility that Lp(a) may be a risk factor for ischemic stroke has been assessed in several studies. Recent findings suggest that Lp(a)-lowering therapy might be beneficial in patients with high Lp(a) levels. A future therapeutic approach could include apheresis in high-risk patients in order to reduce major coronary events.This publication has 111 references indexed in Scilit:
- Lipoprotein(a): Cellular Effects and Molecular MechanismsCholesterol, 2012
- Lipoprotein(a) as a cardiovascular risk factor: current statusEuropean Heart Journal, 2010
- The significance of apolipoprotein-B (Apo-B) in the elderly as a predictive factor of cardio-cerebrovascular complicationsArchives of Gerontology and Geriatrics, 2009
- Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular MortalityJAMA, 2009
- The Apolipoprotein(a) Component of Lipoprotein(a) Stimulates Actin Stress Fiber Formation and Loss of Cell-Cell Contact in Cultured Endothelial CellsOnline Journal of Public Health Informatics, 2004
- Inflammation in atherosclerosisNature, 2002
- Lipoprotein(a) levels in centenariansArchives of Gerontology and Geriatrics, 1996
- Induction of oxygen free radical generation in human monocytes by lipoprotein(a)European Journal of Clinical Investigation, 1994
- Lipoprotein(a) and accelerated coronary artery disease in cardiac transplant recipientsThe Lancet, 1992
- Predictive value of apolipoproteins in a prospective survey of coronary artery disease in menThe American Journal of Cardiology, 1992