Total Synthesis of Leucosceptroids A and B
- 3 December 2014
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 54 (4), 1298-1301
- https://doi.org/10.1002/anie.201410134
Abstract
Leucosceptroids A and B are sesterterpenoids with potent antifeedant and antifungal activities. A more efficient gram‐scale total synthesis of leucosceptroid B and the first total synthesis of leucosceptroid A are presented. The key transformations include an aldol reaction between a substituted dihydrofuranone and an (S)‐citronellal‐derived aldehyde, a SmI2‐mediated intramolecular ketyl–olefin radical cyclization, and final‐stage alcohol oxidation.This publication has 33 references indexed in Scilit:
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