Complex permittivity characterization of serum with an air-bridge enhanced capacitor for quantifiable detection of glucose
- 16 February 2015
- journal article
- Published by AIP Publishing in Applied Physics Letters
- Vol. 106 (7)
- https://doi.org/10.1063/1.4909545
Abstract
We proposed the complex permittivity characterization of serum sample on an air-bridge enhanced capacitor for the mediator-free glucose sensor in the radio frequency of 7.37 GHz. An air-bridge enhanced capacitor with integrated passive device process on a gallium arsenide substrate was implemented for the design, fabrication, and testing to enable effective quantifiable detection of glucose levels in human serum. The decomposition parameters such as complex permittivity, air-bridge capacitance, phase and correlation coefficient were extracted from the measured S-parameter. A high detectable resolution of 0.61 MHz/mg dl−1 and 3.4 pF/mg dl−1 for ten different subjects of serum in the concentration range of 65 to 245 mg/dl at a minimum glucose concentration of 65 mg/dl was realized. The findings support the development of resonance-based sensing by the characterization of complex permittivity with excellent linearity having a correlation coefficient of 0.9979, short assay time of 40 s, limit of quantization of 29.37 mg/dl, and minimum detectable glucose level of about 9.69 mg/dl.Keywords
Funding Information
- Korean government (2012R1A1A2004366)
- National Research Foundation of Korea (2009-0082580, 2011-0030079)
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