A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
- 1 June 1990
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 345 (6277), 686-692
- https://doi.org/10.1038/345686a0
Abstract
The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.This publication has 37 references indexed in Scilit:
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