Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli
- 1 June 1990
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 34 (6), 1271-1272
- https://doi.org/10.1128/aac.34.6.1271
Abstract
Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.Keywords
This publication has 15 references indexed in Scilit:
- Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolonesAntimicrobial Agents and Chemotherapy, 1989
- gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coliAntimicrobial Agents and Chemotherapy, 1989
- Quinolone-resistant mutations of the gyrA gene of Escherichia coliMolecular Genetics and Genomics, 1988
- Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coliMolecular Genetics and Genomics, 1986
- [2] New M13 vectors for cloningMethods in enzymology, 1983
- A rapid boiling method for the preparation of bacterial plasmidsAnalytical Biochemistry, 1981
- Prediction of protein antigenic determinants from amino acid sequences.Proceedings of the National Academy of Sciences of the United States of America, 1981
- Prediction of the Secondary Structure of Proteins from their Amino Acid SequenceAdvances in enzymology and related areas of molecular biology, 1979
- Mode of Incomplete Cross-Resistance Among Pipemidic, Piromidic, and Nalidixic AcidsAntimicrobial Agents and Chemotherapy, 1978
- Nalidixic acid resistance: A second genetic character involved in DNA gyrase activityProceedings of the National Academy of Sciences, 1977