The CounterACT Research Network: Basic Mechanisms and Practical Applications
- 1 July 2010
- journal article
- Published by American Thoracic Society in Proceedings of the American Thoracic Society
- Vol. 7 (4), 254-256
- https://doi.org/10.1513/pats.201001-003sm
Abstract
The National Institutes of Health has developed a comprehensive research program that includes research centers of excellence, individual research projects, small business projects, contracts, and interagency agreements to conduct basic, translational, and clinical research aimed at the discovery and/or identification of better medical countermeasures against chemical threat agents. Chemical threats include chemical warfare agents, toxic industrial and agricultural chemicals, and toxins and other chemicals that could be used intentionally as an act of terror or by large-scale accidents or natural disasters. The overarching goal of this research program is to enhance our medical response capabilities during an emergency. The program is named Countermeasures Against Chemical Threats (CounterACT). It supports translational research, applying ideas, insights, and discoveries generated through basic scientific inquiry to the treatment or prevention of mortality and morbidity caused by chemical threat agents. The categories of research supported under this program include creation and development of screening assays and animal models for therapy development, identification of candidate therapeutics, obtaining preliminary proof-of-principle data on the efficacy of candidate therapeutics, advanced efficacy and preclinical safety studies with appropriate animal models using Good Laboratory Practices (GLP), and clinical studies, including clinical trials with new drugs. Special consideration is given to research relevant to people who are particularly vulnerable, including the young, the elderly, and individuals with pre-existing medical conditions.Keywords
This publication has 6 references indexed in Scilit:
- Acute health effects after exposure to chlorine gas released after a train derailmentThe American Journal of Emergency Medicine, 2009
- Rapid Assessment of Exposure to Chlorine Released from a Train Derailment and Resulting Health ImpactPublic Health Reports, 2007
- Long Term Consequences from Exposure to Sulfur Mustard: A ReviewInhalation Toxicology, 2007
- Bioterrorism.2001
- Sarin poisoning in Matsumoto, JapanThe Lancet, 1995
- Sarin poisoning in Tokyo subwayThe Lancet, 1995