Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
Open Access
- 17 January 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (4), 587-595
- https://doi.org/10.1016/j.febslet.2007.01.013
Abstract
Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re‐differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti‐chlamydial drugs.Keywords
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