Iron Status and Erythrocyte Volume in Dogs With Congenital Portosystemic Vascular Anomalies
Open Access
- 1 January 1997
- journal article
- Published by Wiley in Journal of Veterinary Internal Medicine
- Vol. 11 (1), 14-19
- https://doi.org/10.1111/j.1939-1676.1997.tb00067.x
Abstract
Microcytosis, hypochromasia, and low mean corpuscular hemoglobin are frequent hematologic abnormalities in dogs with portosystemic vascular anomalies (PSVA). The relationship of iron status to these abnormalities is unclear. We evaluated iron status and hematologic and biochemical parameters in dogs with congenital PSVA before (25 dogs) and after (11 dogs) partial ligation of the vascular anomaly. Serum iron concentration and total iron binding capacity were subnormal in 56% and 20% of dogs with PSVA, respectively. Transferrin saturation was normal in 68%, decreased in 20%, and increased in 12% of the dogs. Plasma ferritin concentration was either normal (56%) or high (44%), and was not associated with increases in ceruloplasmin concentration. Hepatic stainable iron was increased in 10 of 16 dogs. Mean corpuscular volume (MCV), mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were decreased in more than 60% of dogs with PSVA. Serum biochemical abnormalities included high bile acid concentration and alanine transaminase (ALT) and alkaline phosphatase (ALP) activities; and low urea, creatinine, cholesterol, and total protein concentrations. Serum iron concentration and clinical status (normal or PSVA) significantly influenced MCV (P= .003 and P < .001, respectively), whereas age, ceruloplasmin, ferritin, cholesterol, bile acids, and total iron binding capacity did not. Partial ligation of PSVA was associated with resolution of clinical signs and the return to normal of iron status and all clinicopathologic abnormalities, except total fasting bile acid concentrations. These findings indicate that iron status is frequently abnormal in dogs with PSVA and that low serum iron concentration appears to be related to the development of microcytosis. The normalization of iron status and clinicopathologic abnormalities after treatment suggests that they are direct consequences of PSVA.Keywords
This publication has 13 references indexed in Scilit:
- Interleukin-6 enhances hepatic transferrin uptake and ferritin expression in ratsHepatology, 1994
- Microcytosis and Iron Status in Dogs With Surgically Induced Portosystemic ShuntsJournal of Veterinary Internal Medicine, 1994
- Hematologic Changes Associated With Serum and Hepatic Iron Alterations in Dogs With Congenital Portosystemic Vascular AnomaliesJournal of Veterinary Internal Medicine, 1994
- An Improved Ferritin Assay for Canine SeraVeterinary Clinical Pathology, 1992
- Erythrocyte Volume Distribution Analysis and Hematologic Changes in Dogs with Iron Deficiency AnemiaVeterinary Pathology, 1983
- Spectrophotometric study of several sensitive reagents for serum ironClinical Biochemistry, 1981
- The effect of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboonsJournal of Surgical Research, 1980
- Defective Renal Handling of Water in the Rat with a Portacaval ShuntEuropean Journal of Clinical Investigation, 1976
- A Clinical Evaluation of Serum Ferritin as an Index of Iron StoresNew England Journal of Medicine, 1974
- ECK FISTULA LIVER SUBNORMAL IN PRODUCING HEMOGLOBIN AND PLASMA PROTEINS ON DIETS RICH IN LIVER AND IRONThe Journal of Experimental Medicine, 1945