Long-Term Rebamipide Therapy Improves Helicobacter pylori-Associated Chronic Gastritis
- 1 January 2002
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Digestive Diseases and Sciences
- Vol. 47 (4), 862-867
- https://doi.org/10.1023/a:1014716822702
Abstract
We investigated an antiinflammatory effect of rebamipide {2-{4-chlorobenzoylamino}-3-[2(1H)-quinolinon-4-yl] propionic acid}, a gastroprotective agent, in H. pylori-associated gastritis. Eighty-six patients with H. pylori-positive chronic gastritis were enrolled: 53 were treated with rebamipide (300 mg daily for 12 months) and 33 served as controls. Significant decreases in mononuclear cell infiltration into the antrum and corpus were noted in the rebamipide treatment group (before vs after, 1.42 ± 0.15 vs 1.02 ± 0.15; P < 0.01 and 1.60 ± 0.15 vs 1.21 ± 0.14; P < 0.05, respectively). Levels of infiltrating neutrophil were also decreased in the antrum (before vs after, 0.98 ± 0.14 vs 0.70 ± 0.13; P < 0.05) and were associated with a decrease in iNOS production. Sera from patients treated with rebamipide showed a significant decrease in gastrin (276.3 ± 58.3 pg/ml vs 173.0 ± 34.2 pg/ml; P < 0.05), whereas no change was observed in the control group. These suggest that long-term rebamipide treatment improved histologic gastritis and decreased serum gastrin levels in H. pylori-associated gastritis.Keywords
This publication has 25 references indexed in Scilit:
- CagA protein from Helicobacter pylori is a Trojan Horse to epithelial cells.Gastroenterology, 2000
- Helicobacter pylori infection is a major risk factor for gastric carcinoma in young patients.2000
- Expression of cell cycle regulators and growth factor/receptor systems in gastric carcinoma in young adults: association with Helicobacter pylori infection.International Journal of Molecular Medicine, 2000
- Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus—evaluation of 24‐h pH monitoringAlimentary Pharmacology & Therapeutics, 1999
- Helicobacter pylori infection, oxidative DNA damage, gastric carcinogenesis, and reversibility by rebamipide.1998
- Helicobacter pylori Infection and Gastric Neoplasia: Correlations With Histological Gastritis and Tumor HistologyThe American Journal of Gastroenterology, 1998
- Helicobacter pylori infection is the major risk factor for atrophic gastritis.1996
- Helicobacter pylori and gastric carcinogenesis.1995
- Mucosal interleukin-8 and Helicobacter pylori-associated gastroduodenal disease.1994
- Enhanced mucosal interleukin-6 and -8 in Helicobacter pylori-positive dyspeptic patients.1994