Effect of heme compounds on lipid oxidation

Abstract
By polarographic oxygen analyzer, the rate of oxidation of linoleate solutions was catalyzed by low concentrations of heme and heme‐proteins and inhibited by higher concentrations. High concentrations of these substances also inhibited lipoxygenase catalysis of linoleate oxidation. Manganese and cobalt salts inhibited heme‐catalyzed linoleate oxidation. These combined effects may reflect the oxidative synthesis of antioxidants from heme compounds.