Human Polyomaviruses in Skin Diseases
Open Access
- 12 September 2011
- journal article
- Published by Hindawi Limited in Pathology Research International
- Vol. 2011, 1-12
- https://doi.org/10.4061/2011/123491
Abstract
Polyomaviruses are a family of small, nonenveloped viruses with a circular double-stranded DNA genome of ∼5,000 base pairs protected by an icosahedral protein structure. So far, members of this family have been identified in birds and mammals. Until 2006, BK virus (BKV), JC virus (JCV), and simian virus 40 (SV40) were the only polyomaviruses known to circulate in the human population. Their occurrence in individuals was mainly confirmed by PCR and the presence of virus-specific antibodies. Using the same methods, lymphotropic polyomavirus, originally isolated in monkeys, was recently shown to be present in healthy individuals although with much lower incidence than BKV, JCV, and SV40. The use of advanced high-throughput sequencing and improved rolling circle amplification techniques have identified the novel human polyomaviruses KI, WU, Merkel cell polyomavirus, HPyV6, HPyV7, trichodysplasia spinulosa-associated polyomavirus, and HPyV9. The skin tropism of human polyomaviruses and their dermatopathologic potentials are the focus of this paper.Keywords
This publication has 109 references indexed in Scilit:
- Merkel cell polyomavirus in naevoid basal cell carcinoma syndrome-associated basal cell carcinomas and sporadic trichoblastomasJournal of Dermatological Science, 2010
- Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T AntigensJournal of Virology, 2010
- Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcomaJournal of Medical Virology, 2009
- Quantitation of Human Seroresponsiveness to Merkel Cell PolyomavirusPLoS Pathogens, 2009
- Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expressionInternational Journal of Cancer, 2009
- Merkel Cell CarcinomaAdvances in Anatomic Pathology, 2009
- The Presence of Polyomavirus in Non-Melanoma Skin Cancer in Organ Transplant Recipients Is RareJournal of Investigative Dermatology, 2009
- Virus-Associated Trichodysplasia SpinulosaThe American Journal of Surgical Pathology, 2005
- Identification of Structural Elements Involved in the Interaction of Simian Virus 40 Small Tumor Antigen with Protein Phosphatase 2APublished by Elsevier BV ,1998
- Patterns of cell communication and differentiation in SV40 transformed human keratinocytesJournal of Cellular Physiology, 1981