Cullin Family Proteins and Tumorigenesis: Genetic Association and Molecular Mechanisms
Open Access
- 1 January 2015
- journal article
- review article
- Published by Ivyspring International Publisher in Journal of Cancer
- Vol. 6 (3), 233-242
- https://doi.org/10.7150/jca.11076
Abstract
Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle progression. Clinically, cullin-associated E3 ligases have been identified to involve numerous human diseases, especially with regard to multiple cancer types. Over the past few years, our understanding of cullin proteins and their functions in genome stability and tumorigenesis has expanded enormously. Herein, this review briefly provides current perspectives on cullin protein functions, and mainly summarizes and discusses molecular mechanisms of cullin proteins in tumorigenesis.Keywords
This publication has 99 references indexed in Scilit:
- Oxidative stress and cancer: An overviewAgeing Research Reviews, 2013
- Flipping the Switch from G1 to S Phase with E3 Ubiquitin LigasesGenes & Cancer, 2012
- Skp2: A novel potential therapeutic target for prostate cancerBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012
- p53 regulation by ubiquitinFEBS Letters, 2011
- Structural assembly of cullin-RING ubiquitin ligase complexesCurrent Opinion in Structural Biology, 2010
- New insights into p53 activationCell Research, 2010
- CRL4s: the CUL4-RING E3 ubiquitin ligasesTrends in Biochemical Sciences, 2009
- Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significanceInternational Journal of Cancer, 2009
- Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis SignalingCell, 2009
- Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 ComplexCell, 2008