Consistency Test of the Cell Cycle: Roles for p53 and EGR1
- 1 March 2012
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 72 (5), 1051-1054
- https://doi.org/10.1158/0008-5472.can-11-3382
Abstract
Mammalian cells are constantly exposed to multiple mitogens and, hence, have developed machineries that help them ignore fortuitous signals. In a recent report in Molecular Cell, we highlighted the molecular details of such a noise-reduction filter, including roles for EGR1, AKT, and p53. Brief exposure to a mitogen drives formation of inhibitory p53-chromatin complexes, which are disabled only if the growth factor is still present several hours later. We propose that this “consistency test” prevents repeated division cycles of normal cells but might become defective in most cancer cells. Cancer Res; 72(5); 1051–4. ©2012 AACR.This publication has 18 references indexed in Scilit:
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