Tumor-intrinsic oncogene pathways mediating immune avoidance
Open Access
- 31 August 2015
- journal article
- review article
- Published by Taylor & Francis Ltd in OncoImmunology
- Vol. 5 (3), e1086862
- https://doi.org/10.1080/2162402x.2015.1086862
Abstract
Immunotherapy is emerging as a major treatment for patients with cancer, predominantly via blocking immune inhibitory pathways and through adoptive T cell therapy. However, only a subset of patients shows clinical responses to these interventions. Emerging data indicates a correlation between clinical response and a pre-existing T cell-inflamed tumor microenvironment. Tumor-intrinsic β-catenin activation has been identified as mediating exclusion of T cells from the tumor microenvironment and other oncogene pathways are being explored similarly. Understanding the molecular mechanisms underlying immune avoidance should identify new therapeutic targets for expanding efficacy of immunotherapies.Keywords
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