Inflammatory mechanisms linking obesity and metabolic disease
Top Cited Papers
Open Access
- 3 January 2017
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 127 (1), 1-4
- https://doi.org/10.1172/jci92035
Abstract
There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration. The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome. We now know that an inflammatory program is activated early in adipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of obesity and inflammation. Reviews in this series examine the activation of the innate and adaptive immune system in obesity; inflammation within diabetic islets, brain, liver, gut, and muscle; the role of inflammation in fibrosis and angiogenesis; the factors that contribute to the initiation of inflammation; and therapeutic approaches to modulate inflammation in the context of obesity and metabolic syndrome.Keywords
This publication has 41 references indexed in Scilit:
- Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin ResistanceCell, 2016
- Regulation of metabolism by the innate immune systemNature Reviews Endocrinology, 2015
- LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytesNature Medicine, 2015
- Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in ObesityCell, 2014
- Immunological Goings-on in Visceral Adipose TissueCell Metabolism, 2013
- Hypoxia and Adipose Tissue Function and Dysfunction in ObesityPhysiological Reviews, 2013
- Omega 3 Fatty Acids and GPR120Cell Metabolism, 2012
- Inflammasome is a central player in the induction of obesity and insulin resistanceProceedings of the National Academy of Sciences of the United States of America, 2011
- Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatmentEMBO Molecular Medicine, 2011
- The global obesity pandemic: shaped by global drivers and local environmentsThe Lancet, 2011