Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
- 1 January 1990
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 343 (6256), 341-346
- https://doi.org/10.1038/343341a0
Abstract
Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A complementary DNA for this molecule has been isolated from a human monocyte library. Analysis of monocyte RNA indicates that the gene is transcriptionally regulated. The sequence of the receptor antagonist indicates that it is structurally similar to IL-lp. Expression of the cDNA in Escherichia coli yields IL-1 receptor antagonist activity.This publication has 34 references indexed in Scilit:
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