Metabolism of inflammation limited by AMPK and pseudo-starvation
Open Access
- 16 January 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 493 (7432), 346-355
- https://doi.org/10.1038/nature11862
Abstract
Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1β and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.Keywords
This publication has 99 references indexed in Scilit:
- The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose MetabolismCell Metabolism, 2012
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory DevelopmentImmunity, 2012
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte ActivationImmunity, 2011
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1Cell, 2011
- AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespanJournal of Molecular Medicine, 2011
- Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK ActivationCell Metabolism, 2010
- Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severityBiochemical and Biophysical Research Communications, 2009
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage CommitmentImmunity, 2009
- An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegansCurrent Biology, 2007
- Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammationCell Metabolism, 2006