Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brain

Abstract
The difference between 1H NMR spectra obtained during eu‐ and hyperglycemia exhibited well‐resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with solution spectra. Estimated increases were consistent with recent 13C NMR quantitations of intracerebral glucose. Difference spectra were measured in 36‐ml volumes from the human brain every 3 min.