GenePRIMP: a gene prediction improvement pipeline for prokaryotic genomes
- 2 May 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Methods
- Vol. 7 (6), 455-457
- https://doi.org/10.1038/nmeth.1457
Abstract
We present 'gene prediction improvement pipeline' (GenePRIMP; http://geneprimp.jgi-psf.org/), a computational process that performs evidence-based evaluation of gene models in prokaryotic genomes and reports anomalies including inconsistent start sites, missed genes and split genes. We found that manual curation of gene models using the anomaly reports generated by GenePRIMP improved their quality, and demonstrate the applicability of GenePRIMP in improving finishing quality and comparing different genome-sequencing and annotation technologies.Keywords
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