Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus
- 1 January 1984
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 307 (5949), 334-340
- https://doi.org/10.1038/307334a0
Abstract
A tissue-specific transcriptional enhancer element that is associated with the human immunoglobulin heavy-chain locus is defined. In a non-Hodgkin's lymphoma that contains a translocated c-myc gene this enhancer is retained on the 14q+ chromosome and occurs within sequences shown to activate previously cryptic promoters of the c-myc gene.Keywords
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