Nature of Inflammatory Infiltrate in Superficial Cutaneous Malignancies During Topical Imiquimod Treatment
- 1 June 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Dermatopathology
- Vol. 29 (3), 237-241
- https://doi.org/10.1097/01.dad.0000211531.33670.94
Abstract
Topical imiquimod (IQ) is an effective treatment for genital warts and various malignant tumors of the skin. IQ acts through the Toll-like receptor 7 leading to the production of cytokines and chemokines such as interferons, interleukins, and growth factors. We investigated the composition of the inflammatory cell infiltrate before, during, and after the treatment of 10 superficial cutaneous malignancies (melanoma in situ (n = 4), melanoma metastasis (n = 1), squamous cell carcinoma in situ (n = 4), and basal cell carcinoma (n = 1) with 5% IQ cream. Immunophenotyping revealed in all cases during treatment an increased population of T-lymphocytes positive for CD3, CD4 and CD8, as well as a considerable number of cytotoxic cells (TIA-1+, granzyme B+) and plasmacytoid dendritic cells (CD 123+). These findings further support previous investigations that the antitumor effects of IQ result from an enhanced cytotoxic T-cell mediated immune response and from the recruitment of plasmacytoid dendritic cells to the skin. The population of infiltrative inflammatory cells was similar in all patients irrespective of the type of tumor.Keywords
This publication has 18 references indexed in Scilit:
- The Role of Toll-like Receptors in the Pathogenesis and Treatment of Dermatological DiseaseJournal of Investigative Dermatology, 2005
- Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in EuropeBritish Journal of Dermatology, 2005
- Treatment of Lentigo Maligna (Melanoma In Situ) With the Immune Response Modifier ImiquimodArchives of Dermatology, 2005
- Dosing With 5% Imiquimod Cream 3 Times per Week for the Treatment of Actinic KeratosisArchives of Dermatology, 2005
- Characterization of the cellular infiltrate during successful topical treatment of lentigo maligna with imiquimodBritish Journal of Dermatology, 2004
- Topical imidazoquinoline therapy of cutaneous squamous cell carcinoma polarizes lymphoid and monocyte/macrophage populations to a Th1 and M1 cytokine patternClinical and Experimental Dermatology, 2004
- Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trialsJournal of the American Academy of Dermatology, 2004
- Immune modulation and apoptosis induction: Two sides of the antitumoral activity of imiquimodApoptosis, 2004
- Treatment of lentigo maligna with topical imiquimodBritish Journal of Dermatology, 2003
- Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: A comparative studyJournal of the American Academy of Dermatology, 1990