Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques
Open Access
- 12 December 2005
- journal article
- Published by Springer Science and Business Media LLC in Analytical Sciences
- Vol. 21 (12), 1443-1448
- https://doi.org/10.2116/analsci.21.1443
Abstract
New ranitidine hydrochloride (RaCl)-selective electrodes of the conventional polymer membrane type are described. They are based on incorporation of ranitidine-tetraphenylborate (Ra-TPB) ion-pair or ranitidine-phosphotungstate (Ra-PT) ion-associate in a poly(vinyl chloride) (PVC) membrane plasticized with dioctylphthalate (DOP) or dibutylphthalate (DBP). The electrodes are fully characterized in terms of the membrane composition, solution temperature, and pH. The sensors showed fast and stable responses. Nernstian response was found over the concentration range of 2.0 × 10-5 M to 1.0 × 10-2 M and 1.0 × 10-5 M to 1.0 × 10-2 M in the case of Ra-TPB electrode and over the range of 1.03 × 10-5 M to 1.00 × 10-2 M and 1.0 × 10-5 M to 1.0 × 10-2 M in the case of Ra-PT electrode for batch and FIA systems, respectively. The electrodes exhibit good selectivity for RaCl with respect to a large number of common ions, sugars, amino acids, and components other than ranitidine hydrochloride of the investigated mixed drugs. The electrodes have been applied to the potentiometric determination of RaCl in pure solutions and in pharmaceutical preparations under batch and flow injection conditions with a lower detection limit of 1.26 × 10-5 M and 5.62 × 10-6 M at 25 ± 1°C. An average recovery of 100.91% and 100.42% with a relative standard deviation of 0.72% and 0.53% has been achieved.Keywords
This publication has 22 references indexed in Scilit:
- Direct determination of ranitidine and famotidine by CE in serum, urine and pharmaceutical formulationsJournal of Pharmaceutical and Biomedical Analysis, 2002
- Flow-injection extraction-spectrophotometric method for the determination of ranitidine in pharmaceutical preparationsJournal of Pharmaceutical and Biomedical Analysis, 2001
- Potentiometric Selectivity Coefficients of Ion-Selective Electrodes. Part I. Inorganic Cations (Technical Report)Pure and Applied Chemistry, 2000
- Spectrophotometric and Spectrofluorimetric Determination of Famotidine and Ranitidine Using 1,4-Benzoquinone ReagentAnalytical Letters, 1999
- Flow injection potentiometry by poly(vinyl chloride)-membrane electrodes with substituted azacrown ionophores for the determination of lead(II) and mercury(II) ionsAnalytica Chimica Acta, 1998
- Application of Azine Dyes for the Determination of Ranitidine Hydrochloride in Pharmaceutical FormulationsAnalytical Letters, 1997
- Quantitavive Proton Magnetic Resonance Analysis of Ranitidine in Solid Dosage FormsSpectroscopy Letters, 1997
- Application of near-infrared reflectance spectrometry to the analytical control of pharmaceuticals: ranitidine hydrochloride tablet productionThe Analyst, 1996
- Ion-selective membrane electrodes for the determination of the muscle relaxants pancuronium, tubocurarine, gallamine and succinylcholineAnalytica Chimica Acta, 1990
- Limitation of linear response in flow-injection systems with ion-selective electrodesAnalytica Chimica Acta, 1982