Antibiotic Management of Staphylococcus aureus Infections in US Children's Hospitals, 1999–2008
- 1 June 2010
- journal article
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 125 (6), e1294-e1300
- https://doi.org/10.1542/peds.2009-2867
Abstract
OBJECTIVES: The objective of this study was to describe trends in antibiotic management for Staphylococcus aureus infections among hospitalized children from 1999 to 2008. METHODS: A retrospective study was conducted by using the Pediatric Health Information Systems database to describe antibiotic treatment of inpatients with S aureus infection at 25 children's hospitals in the United States. Patients who were admitted from 1999 to 2008 with International Classification of Diseases, Ninth Revision, Clinical Modification codes for S aureus infection were included. Trends in the use of vancomycin, clindamycin, linezolid, trimethoprim-sulfamethoxazole, cefazolin, and oxacillin/nafcillin were examined for percentage use and days of therapy per 1000 patient-days. RESULTS: A total of 64813 patients had a discharge diagnosis for S aureus infection. The incidence of methicillin-resistant S aureus (MRSA) infections during this period increased 10-fold, from 2 to 21 cases per 1000 admissions, whereas the methicillin-susceptible S aureus infection rate remained stable. Among patients with S aureus infections, antibiotics that treat MRSA increased from 52% to 79% of cases, whereas those that treat only methicillin-susceptible S aureus declined from 66% to CONCLUSIONS: Antibiotic prescribing patterns for the treatment of S aureus infections have changed significantly during the past decade, reflecting the emergence of community-associated MRSA. Clindamycin is now the most commonly prescribed antibiotic for S aureus infections among hospitalized children. The substantial use of clindamycin emphasizes the importance of continuous monitoring of local S aureus susceptibility patterns.This publication has 24 references indexed in Scilit:
- Pediatric and NeonatalStaphylococcus aureusBacteremia Epidemiology, Risk Factors, and OutcomeInfection Control & Hospital Epidemiology, 2009
- Trends in the Incidence of Methicillin‐ResistantStaphylococcus aureusInfection in Children’s Hospitals in the United StatesClinical Infectious Diseases, 2009
- Knowledge and Use of Cumulative Antimicrobial Susceptibility Data at a University Teaching HospitalClinical Infectious Diseases, 2008
- Methicillin‐ResistantStaphylococcus aureus:An Evolving Clinical ChallengeClinical Infectious Diseases, 2008
- Management of multidrug-resistant organisms in health care settings, 2006American Journal of Infection Control, 2007
- Incidence of Constitutive and Inducible Clindamycin Resistance in Staphylococcus aureus and Coagulase-Negative Staphylococci in a Community and a Tertiary Care HospitalJournal of Clinical Microbiology, 2004
- Clindamycin treatment of invasive infections caused by community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus in childrenThe Pediatric Infectious Disease Journal, 2003
- Epidemiology of Methicillin-Resistant Staphylococcus aureus at a Children's HospitalInfection Control & Hospital Epidemiology, 2003
- Increase in Community‐Acquired Methicillin‐ResistantStaphylococcus aureusin ChildrenClinical Infectious Diseases, 1999
- Methicillin-Resistant Staphylococcus aureus as a Community OrganismClinical Infectious Diseases, 1995