All oxygens in nucleic acids react with carcinogenic ethylating agents
- 25 November 1976
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 264 (5584), 333-339
- https://doi.org/10.1038/264333a0
Abstract
Over 80% of ethylnitrosourea and ethylnitrosoguanidine modification of nucleic acids is on oxygens. The reactivity of oxygens (other than ribose and phosphate) in single-stranded RNA is: O2of C > O2 of U > O6 of G > O4 of U. In double-stranded DNA the order is: O2 of T = O6 of G > O4 of T ≫ O2 of C. Oxygen reactivity of single-stranded DNA resembles RNA. The glycosidic bond of O2-alkylpyrimidines is labilised.Keywords
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