Endoplasmic reticulum aminopeptidases: biochemistry, physiology and pathology
Open Access
- 12 July 2013
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 154 (3), 219-228
- https://doi.org/10.1093/jb/mvt066
Abstract
The human endoplasmic reticulum aminopeptidase (ERAP) 1 and 2 proteins were initially identified as homologues of human placental leucine aminopeptidase/insulin-regulated aminopeptidase. They are categorized as a unique class of proteases based on their subcellular localization on the luminal side of the endoplasmic reticulum. ERAPs play an important role in the N-terminal processing of the antigenic precursors that are presented on the major histocompatibility complex (MHC) class I molecules. ERAPs are also implicated in the regulation of a wide variety of physiological phenomena and pathogenic conditions. In this review, the current knowledge on ERAPs is summarized.Keywords
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