A Coumarin from Mallotus resinosus that Mediates DNA Cleavage
- 12 August 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 67 (9), 1614-1616
- https://doi.org/10.1021/np040129c
Abstract
A crude extract prepared from roots of Mallotus resinosus exhibited significant Cu2+-dependent DNA strand scission activity and was thus selected for bioassay-guided fractionation. Scopoletin (1), a simple coumarin, was identified as the active principle responsible for DNA cleavage activity of the crude extract. The DNA strand scission activity of 1, as well as that of three structural analogues, is reported.This publication has 19 references indexed in Scilit:
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