Identifying protective antigens ofStaphylococcus aureus, a pathogen that suppresses host immune responses
Open Access
- 13 July 2011
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 25 (10), 3605-3612
- https://doi.org/10.1096/fj.11-187963
Abstract
Staphylococcus aureus infections result in abscesses as well as septicemia. Even with therapy, abscesses can persist or even reoccur, as staphylococcal infections fail to induce protective immune responses. Here, we show that prior infection with certain attenuated strains may elicit protective immunity. A closer examination reveals that protection correlates with antibody responses elicited on exposure to particular attenuated variants. Linear regression analysis was used to compare reduction in staphylococcal disease and antibody responses to infection with wild-type and attenuated variants. This analysis identified protective antigens that, when tested as vaccines in mice, elicited disease protection. Protection afforded by attenuated strains correlates in part with the ability of Staphylococcus aureus to modulate B cell responses via protein A (spa encoded). We designate this approach “genetic vaccinology,” since it exploits genetic variants to draw a correlation between disease protection and humoral immune responses for the deduction of vaccine antigens. Genetic vaccinology is particularly useful for microbes that do not elicit natural protective immunity during infection.—Kim, H. K., Kim, H. -Y., Schneewind, O., Missiakas, D. Identifying protective antigens of Staphylococcus aureus, a pathogen that suppresses host immune responses. FASEB J. 25, 3605–3612 (2011). www.fasebj.orgKeywords
Funding Information
- National Institute of Allergy and Infectious Diseases
This publication has 43 references indexed in Scilit:
- IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challengeVaccine, 2010
- Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in miceThe Journal of Experimental Medicine, 2010
- Staphylococcus aureus synthesizes adenosine to escape host immune responsesThe Journal of Experimental Medicine, 2009
- Waves of resistance: Staphylococcus aureus in the antibiotic eraNature Reviews Microbiology, 2009
- Genetic requirements forStaphylococcus aureusabscess formation and persistence in host tissuesThe FASEB Journal, 2009
- ESX/type VII secretion systems and their role in host–pathogen interactionCurrent Opinion in Microbiology, 2009
- Vaccine protection againstStaphylococcus aureuspneumoniaThe Journal of Experimental Medicine, 2008
- Vaccine assembly from surface proteins ofStaphylococcus aureusProceedings of the National Academy of Sciences of the United States of America, 2006
- Confounding B-cell defences: lessons from a staphylococcal superantigenNature Reviews Immunology, 2006
- A Novel Staphylococcus aureus Vaccine: Iron Surface Determinant B Induces Rapid Antibody Responses in Rhesus Macaques and Specific Increased Survival in a Murine S. aureus Sepsis ModelInfection and Immunity, 2006