Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection
Top Cited Papers
- 8 March 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Archiv für die gesamte Virusforschung
- Vol. 158 (7), 1445-1459
- https://doi.org/10.1007/s00705-013-1645-3
Abstract
Today, dengue viruses are the most prevalent arthropod-borne viruses in the world. Since the 1960s, numerous reports have identified a second heterologous dengue virus (DENV) infection as a principal risk factor for severe dengue disease (dengue hemorrhagic fever/dengue shock syndrome, DHF/DSS). Modifiers of dengue disease response include the specific sequence of two DENV infections, the interval between infections, and contributions from the human host, such as age, ethnicity, chronic illnesses and genetic background. Antibody-dependent enhancement (ADE) of dengue virus infection has been proposed as the early mechanism underlying DHF/DSS. Dengue cross-reactive antibodies raised following a first dengue infection combine with a second infecting virus to form infectious immune complexes that enter Fc-receptor-bearing cells. This results in an increased number of infected cells and increased viral output per cell. At the late illness stage, high levels of cytokines, possibly the result of T cell elimination of infected cells, result in vascular permeability, leading to shock and death. This review is focused on the etiological role of secondary infections (SI) and mechanisms of ADE.Keywords
This publication has 140 references indexed in Scilit:
- Partial maturation: an immune-evasion strategy of dengue virus?Trends in Microbiology, 2011
- Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexesThe Lancet Infectious Diseases, 2010
- Dengue virus neutralization is modulated by IgG antibody subclass and Fcγ receptor subtypeVirology, 2009
- Dengue in Vietnamese Infants—Results of Infection‐Enhancement Assays Correlate with Age‐Related Disease Epidemiology, and Cellular Immune Responses Correlate with Disease SeverityThe Journal of Infectious Diseases, 2008
- Molecular mechanisms of antibody-mediated neutralisation of flavivirus infectionExpert Reviews in Molecular Medicine, 2008
- Decreases in dengue transmission may act to increase the incidence of dengue hemorrhagic feverProceedings of the National Academy of Sciences of the United States of America, 2008
- Monoclonal antibody-mediated enhancement of dengue virus infectionin vitroandin vivoand strategies for preventionProceedings of the National Academy of Sciences of the United States of America, 2007
- Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in BangkokProceedings of the National Academy of Sciences of the United States of America, 2006
- Ecological and immunological determinants of dengue epidemicsProceedings of the National Academy of Sciences of the United States of America, 2006
- A structural perspective of the flavivirus life cycleNature Reviews Microbiology, 2005