Unmetabolized Polycyclic Aromatic Hydrocarbons in Urine as Biomarkers of Low Exposure in Asphalt Workers
- 14 May 2007
- journal article
- research article
- Published by Informa UK Limited in Journal of Occupational and Environmental Hygiene
- Vol. 4 (sup1), 100-110
- https://doi.org/10.1080/15459620701322645
Abstract
The aim of the study was the assessment of low-level exposure to polycyclic aromatic hydrocarbons (PAHs) by biological monitoring focusing on measurement of unmetabolized PAHs in urine. Italian asphalt workers (AW, n = 100) and roadside construction workers (CW, n = 47) were investigated by measurement of unmetabolized PAHs and 1-hydroxypyrene (OH-Py) in urine spot samples collected respectively after two days of vacation (baseline), before and at the end of the monitored workshift, in the second part of the workweek. Personal exposure was also assessed by use of active samplers collecting both vapor- and particulate-phase PAHs. Median airborne levels during the workshift of 15 PAHs (both vapor and particulate phases), from naphthalene to indeno(1,2,3-cd)pyrene, ranged from below 0.03 to 426 ng/m 3 . Median excretion values of OH-Py in end-shift samples was 690 ng/L for AW and 378 ng/L for CW (p < 0.01). Urinary low-boiling PAHs were detected in the majority of the samples. Median levels for urinary naphthalene, phenanthrene, fluoranthene, and pyrene in end-shift samples were 117, 50, 8, and 6 ng/L in AW and 104, 19, 5, and 4 ng/L in CW, respectively. Significantly higher levels of most of the unmetabolized compounds were found in AW than in CW. Moreover, in AW samples the urinary excretion of most analytes increased during the work shift (before-shift vs. end-shift) and the workweek (baseline vs. before-shift). Urinary high-boiling PAHs were found in less than 10% of the samples. Significant correlations between airborne and urinary PAHs were observed. The results of this study show that low-boiling unmetabolized PAHs in urine may be suggested as biomarkers of low-level exposure to PAHs.Keywords
This publication has 38 references indexed in Scilit:
- Comparison Between Urinaryo-Cresol and Toluene as Biomarkers of Toluene ExposureJournal of Occupational and Environmental Hygiene, 2007
- Polyurethane foam chips combined with liquid chromatography in the determination of unmetabolized polycyclic aromatic hydrocarbons excreted in human urineBiomedical Chromatography, 2006
- Biological monitoring of exposure to polycyclic aromatic hydrocarbons by determination of unmetabolized compounds in urineToxicology Letters, 2005
- Dermal Exposure to Polycyclic Aromatic Hydrocarbons among Road PaversAnnals of Occupational Hygiene, 2005
- Inhalation and Dermal Exposure among Asphalt Paving WorkersAnnals of Occupational Hygiene, 2004
- Sidestream tobacco smoke as the main predictor of exposure to polycyclic aromatic hydrocarbonsJournal of Applied Toxicology, 2004
- Urinary excretion of 1-hydroxypyrene as a biomarker of exposure to polycyclic aromatic hydrocarbons from different sourcesBiomarkers, 2000
- Determination of Naphthalene in Urine by Purge-and-Trap Gas ChromatographyPolycyclic Aromatic Compounds, 1999
- INTERPRETATION OF URINE RESULTS USED TO ASSESS CHEMICAL EXPOSURE WITH EMPHASIS ON CREATININE ADJUSTMENTS: A REVIEWAihaj Journal, 1993
- Potential of micelle-mediate procedures in the sample preparation steps for the determination of polynuclear aromatic hydrocarbons in watersAnalytica Chimica Acta, 1992