Glycated albumin: a potential biomarker in diabetes
Open Access
- 1 June 2017
- journal article
- review article
- Published by Archives of Endocrinology and Metabolism in Archives of Endocrinology and Metabolism
- Vol. 61 (3), 296-304
- https://doi.org/10.1590/2359-3997000000272
Abstract
Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron deficiency anemia, hemoglobinopathies, pregnancy, and uremia. The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels. GA is the higher glycated portion of fructosamine. It is measured by a standardized enzymatic methodology, easy and fast to perform. These laboratory characteristics have ensured the highlight of GA in studies from the last decade, as a marker of monitoring and screening for DM, as well as a predictor of long-term outcomes of the disease. The aim of this review was to discuss the physiological and biochemistry characteristics of the GA, as well as its clinical utility in DM.Keywords
This publication has 55 references indexed in Scilit:
- Glycated albumin is the preferred marker for assessing glycaemic control in advanced chronic kidney diseaseClinical Kidney Journal, 2011
- Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes MellitusClinical Chemistry, 2011
- The glycation of albumin: Structural and functional impactsBiochimie, 2011
- Association Between Iron Deficiency and A1C Levels Among Adults Without Diabetes in the National Health and Nutrition Examination Survey, 1999–2006Diabetes Care, 2010
- Comparison of Glycated Albumin and Hemoglobin A1c Concentrations in Diabetic Subjects on Peritoneal and HemodialysisPeritoneal Dialysis International, 2010
- A1C but Not Serum Glycated Albumin Is Elevated Because of Iron Deficiency in Late Pregnancy in Diabetic WomenDiabetes Care, 2009
- Comparison of A1C and Fasting Glucose Criteria to Diagnose Diabetes Among U.S. AdultsDiabetes Care, 2009
- Structural and glycation site changes of albumin in diabetic patient with very high glycated albuminClinica Chimica Acta; International Journal of Clinical Chemistry, 2007
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusThe New England Journal of Medicine, 1993