PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Top Cited Papers
Open Access
- 1 March 2006
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 116 (3), 615-622
- https://doi.org/10.1172/jci27794
Abstract
Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.Keywords
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