Molecular mediators of hepatic steatosis and liver injury
Top Cited Papers
Open Access
- 15 July 2004
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 114 (2), 147-152
- https://doi.org/10.1172/jci200422422
Abstract
Obesity and its associated comorbidities are among the most prevalent and challenging conditions confronting the medical profession in the 21st century. A major metabolic consequence of obesity is insulin resistance, which is strongly associated with the deposition of triglycerides in the liver. Hepatic steatosis can either be a benign, noninflammatory condition that appears to have no adverse sequelae or can be associated with steatohepatitis: a condition that can result in end-stage liver disease, accounting for up to 14% of liver transplants in the US. Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis.Keywords
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