pH-Responsive Nanoparticles for Drug Delivery
Top Cited Papers
- 13 September 2010
- journal article
- review article
- Published by American Chemical Society (ACS) in Molecular Pharmaceutics
- Vol. 7 (6), 1913-1920
- https://doi.org/10.1021/mp100253e
Abstract
First-generation nanoparticles (NPs) have been clinically translated as pharmaceutical drug delivery carriers for their ability to improve on drug tolerability, circulation half-life, and efficacy. Toward the development of the next-generation NPs, researchers have designed novel multifunctional platforms for sustained release, molecular targeting, and environmental responsiveness. This review focuses on environmentally responsive mechanisms used in NP designs, and highlights the use of pH-responsive NPs in drug delivery. Different organs, tissues, and subcellular compartments, as well as their pathophysiological states, can be characterized by their pH levels and gradients. When exposed to these pH stimuli, pH-responsive NPs respond with physicochemical changes to their material structure and surface characteristics. These include swelling, dissociating or surface charge switching, in a manner that favors drug release at the target site over surrounding tissues. The novel developments described here may revise the classical outlook that NPs are passive delivery vehicles, in favor of responsive, sensing vehicles that use environmental cues to achieve maximal drug potency.Keywords
This publication has 84 references indexed in Scilit:
- Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer DrugsScience, 2010
- Polymer−Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug DeliveryACS Nano, 2009
- pH Controlled Release of Chromone from Chromone-Fe3O4 NanoparticlesJournal of the American Chemical Society, 2008
- A Smart Nanoassembly Consisting of Acid-Labile Vinyl Ether PEG−DOPE and Protamine for Gene Delivery: Preparation and in Vitro TransfectionBiomacromolecules, 2008
- Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugsJournal of Controlled Release, 2008
- Recent progress in tumor pH targeting nanotechnologyJournal of Controlled Release, 2008
- Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptidesAdvanced Drug Delivery Reviews, 2007
- Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytesProceedings of the National Academy of Sciences of the United States of America, 2007
- Sheddable Coatings for Long-Circulating NanoparticlesPharmaceutical Research, 2007
- Polymeric Particulates to Improve Oral Bioavailability of Peptide DrugsMolecules, 2005