HYPOTHALAMO-PITUITARY ADRENOCORTICAL FUNCTION IN THE RAT AFTER TREATMENT WITH BETAMETHASONE
Open Access
- 1 February 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 56 (2), 235-239
- https://doi.org/10.1111/j.1476-5381.1976.tb07447.x
Abstract
1 Hypothalamo-pituitary-adrenocortical (HPA) activity was suppressed in rats treated with betamethasone. 2 Recovery of normal HPA function occurred after corticosteroid withdrawal. 3 Although corticotrophin release was rapidly restored to its basal rate there was a delay in the return of the normal adrenocorticotrophic response to stress and normal adrenocortical function was evident only after the plasma adrenocorticotrophic hormone had reached ‘supra-normal’ levels. 4 The physiological significance and possible clinical relevance of the results are discussed.Keywords
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