Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist
- 27 August 2009
- journal article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 16 (9), 564-572
- https://doi.org/10.1101/lm.1448009
Abstract
The striatum plays a major role in both motor control and learning and memory, including executive function and “behavioral flexibility.” Lesion, temporary inactivation, and infusion of an N-methyl-d-aspartate (NMDA)-receptor antagonist into the dorsomedial striatum (dmSTR) impair reversal learning in adult rats. Systemic administration of MK-801 disrupts reversal learning in developing rats, as reported in an earlier work by Chadman et al., but it is not known whether NMDA-receptor function within the dmSTR plays a role in this effect. In Experiment 1, reversal learning was dose-dependently impaired following bilateral dmSTR administration of MK-801 (either 2.5 or 5.0 μg) only during the reversal phase relative to saline in postnatal day (P) 26 rats. In Experiment 2, separate groups of P26 rats were trained on the same reversal learning task, but were administered bilateral dmSTR infusions during acquisition only (MK–SAL), reversal only (SAL–MK), both phases (MK–MK), or neither phase (SAL–SAL). The MK-801 effect was specific to the reversal training phase. The drug did not alter acquisition of the initial discrimination. Analysis of the pattern of errors indicates that dmSTR MK-801 treatment increased perseveration of the choice response trained in acquisition. NMDA receptors in the dmSTR play a role in reversal learning in the weanling rat.Keywords
This publication has 45 references indexed in Scilit:
- Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling ratsNeurobiology of Learning and Memory, 2009
- Pontine stimulation overcomes developmental limitations in the neural mechanisms of eyeblink conditioningLearning & Memory, 2005
- The contribution of NMDA receptors in the dorsolateral striatum to egocentric response learning.Behavioral Neuroscience, 2005
- Contextual modulation of spatial discrimination reversal in developing ratsDevelopmental Psychobiology, 2004
- Dorsal hippocampus and classical fear conditioning to tone and context in rats: Effects of local NMDA‐receptor blockade and stimulationHippocampus, 2003
- Learning and Memory Functions of the Basal GangliaAnnual Review of Neuroscience, 2002
- Eyeblink conditioning in the infant rat: an animal model of learning in developmental neurotoxicology.Environmental Health Perspectives, 1994
- Developmental and regional expression in the rat brain and functional properties of four NMDA receptorsNeuron, 1994
- Contextual control of conflicting associations in the developing ratDevelopmental Psychobiology, 1992
- Role of the caudate nucleus in recovery from neonatal mediofrontal cortex lesions in the ratDevelopmental Psychobiology, 1984