Biomolecular Interaction Study of Cyclolinopeptide A with Human Serum Albumin
Open Access
- 1 January 2010
- journal article
- research article
- Published by Hindawi Limited in Journal of Biomedicine and Biotechnology
- Vol. 2010, 1-8
- https://doi.org/10.1155/2010/737289
Abstract
The kinetics, energetics, and structure of Cyclolinopeptide A binding with Human Serum Albumin were investigated with surface plasmon resonance and circular dichroism. The complex is formed through slow recognition kinetics that is temperature sensitive in the range of 20°C–37°C. The overall reaction was observed to be endothermic ( kJ) and entropy driven ( J) with overall small changes to the tertiary structure.
Keywords
Funding Information
- Natural Sciences and Engineering Research Council of Canada
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