Advances and New Directions in Crystallization Control
Top Cited Papers
- 15 July 2012
- journal article
- review article
- Published by Annual Reviews in Annual Review of Chemical and Biomolecular Engineering
- Vol. 3 (1), 55-75
- https://doi.org/10.1146/annurev-chembioeng-062011-081043
Abstract
The academic literature on and industrial practice of control of solution crystallization processes have seen major advances in the past 15 years that have been enabled by progress in in-situ real-time sensor technologies and driven primarily by needs in the pharmaceutical industry for improved and more consistent quality of drug crystals. These advances include the accurate measurement of solution concentrations and crystal characteristics as well as the first-principles modeling and robust model-based and model-free feedback control of crystal size and polymorphic identity. Research opportunities are described in model-free controller design, new crystallizer designs with enhanced control of crystal size distribution, strategies for the robust control of crystal shape, and interconnected crystallization systems for multicomponent crystallization.Keywords
This publication has 100 references indexed in Scilit:
- A Stochastic Model for Nucleation Kinetics Determination in Droplet-Based Microfluidic SystemsCrystal Growth & Design, 2010
- Continuous Plug Flow Crystallization of Pharmaceutical CompoundsCrystal Growth & Design, 2010
- Combined Quadrature Method of Moments and Method of Characteristics Approach for Efficient Solution of Population Balance Models for Dynamic Modeling and Crystal Size Distribution Control of Crystallization ProcessesIndustrial & Engineering Chemistry Research, 2009
- Laterally Mobile, Functionalized Self-Assembled Monolayers at the Fluorous−Aqueous Interface in a Plug-Based Microfluidic System: Characterization and Testing with Membrane Protein CrystallizationJournal of the American Chemical Society, 2009
- Modeling and Computational Fluid Dynamics−Population Balance Equation−Micromixing Simulation of Impinging Jet CrystallizersCrystal Growth & Design, 2008
- The Evolution of Crystal Shape During Dissolution: Predictions and ExperimentsCrystal Growth & Design, 2008
- Determination of the Kinetic Parameters for the Crystallization of Paracetamol from Water Using Metastable Zone Width ExperimentsIndustrial & Engineering Chemistry Research, 2008
- Multi-objective optimization of seeded batch crystallization processesChemical Engineering Science, 2006
- An algorithm for analyzing noisy, in situ images of high-aspect-ratio crystals to monitor particle size distributionChemical Engineering Science, 2006
- Advanced control of crystallization processesAnnual Reviews in Control, 2002