Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
Open Access
- 13 June 2011
- journal article
- Published by Springer Science and Business Media LLC in Molecular Brain
- Vol. 4 (1), 26
- https://doi.org/10.1186/1756-6606-4-26
Abstract
Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance.Keywords
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