The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases
Top Cited Papers
Open Access
- 28 December 2010
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 63 (3), 633-639
- https://doi.org/10.1002/art.30155
Abstract
Objective Understanding of the personal risks for rheumatoid arthritis (RA) and other rheumatic diseases remains poor, despite advances in knowledge with regard to their pathogenesis, therapeutics, and clinical impact, in part because the personal lifetime risk of developing these diseases is unknown. This study was undertaken to estimate the lifetime risk of RA, as well as other inflammatory autoimmune rheumatic diseases, including systemic lupus erythematosus, psoriatic arthritis, polymyalgia rheumatica (PMR), giant cell arteritis, ankylosing spondylitis, and Sjögren's syndrome, and to provide an overall estimate of the risk of developing inflammatory autoimmune rheumatic disease over a lifetime. Methods Using the incidence rates obtained from our population‐based studies of rheumatic diseases among residents of Olmsted County, Minnesota, and mortality rates from life tables for the general population, we estimated the sex‐specific lifetime risk of rheumatic disease. Results The lifetime risk of RA developing in US adults was 3.6% for women and 1.7% for men, and the lifetime risk of rheumatoid factor–positive RA was 2.4% for women and 1.1% for men. The second most common inflammatory autoimmune rheumatic disease was PMR, with a lifetime risk of 2.4% for women and 1.7% for men. The overall lifetime risk of inflammatory autoimmune rheumatic disease was 8.4% for women and 5.1% for men. Conclusion One in 12 women and 1 in 20 men will develop an inflammatory autoimmune rheumatic disease during their lifetime. These results can serve as useful guides in counseling patients regarding their lifetime risk of these conditions and have important implications regarding disease awareness campaigns.This publication has 30 references indexed in Scilit:
- Is the incidence of rheumatoid arthritis rising?: Results from Olmsted County, Minnesota, 1955–2007Arthritis & Rheumatism, 2010
- Familial associations of rheumatoid arthritis with autoimmune diseases and related conditionsArthritis & Rheumatism, 2009
- Time Trends in Epidemiology and Characteristics of Psoriatic Arthritis Over 3 Decades: A Population-based StudyThe Journal of Rheumatology, 2009
- Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseasesArthritis Research & Therapy, 2009
- Geographic Variation in Rheumatoid Arthritis Incidence Among Women in the United StatesJAMA Internal Medicine, 2008
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part IArthritis & Rheumatism, 2007
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part IIArthritis & Rheumatism, 2007
- Primer: demystifying risk—understanding and communicating medical risksNature Clinical Practice Rheumatology, 2007
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- Evaluation of Diagnostic Criteria for Ankylosing SpondylitisArthritis & Rheumatism, 1984