The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome
Open Access
- 21 March 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 7 (1), srep44784
- https://doi.org/10.1038/srep44784
Abstract
We investigated whether N-terminal proB-type natriuretic peptide (NT-proBNP) predicts the prognosis of patients with acute respiratory distress syndrome (ARDS). Between December 1, 2012, and May 31, 2015, this observational study recruited patients admitted to our tertiary medical center who met the Berlin criteria for ARDS and who had their NT-proBNP measured. The main outcome was 28-day mortality. We enrolled 61 patients who met the Berlin criteria for ARDS: 7 were classified as mild, 29 as moderate, and 25 as severe. The median APACHE II scores were 23 (interquartile range [IQR], 18–28), and SOFA scores were 11 (IQR, 8–13). The median lung injury score was 3.0 (IQR, 2.50–3.25), and the median level of NT-proBNP was 2011 pg/ml (IQR, 579–7216). Thirty-four patients died during this study, and the 28-day mortality rate was 55.7%. Patients who die were older and had significantly (all p < 0.05) higher APACHE II scores and NT-proBNP levels than did patients who survived. Multivariate analysis identified age (HR: 1.546, 95% CI: 1.174–2.035, p = 0.0019) and NT-proBNP (HR: 1.009, 95% CI: 1.004–1.013, p = 0.0001) as significant risk factors of death. NT-proBNP was associated with poor outcomes for patients with ARDS, and its level predicted mortality.Keywords
This publication has 26 references indexed in Scilit:
- Serum levels of N–terminal proB–type natriuretic peptide in mechanically ventilated critically ill patients – relation to tidal volume size and development of acute respiratory distress syndromeBMC Pulmonary Medicine, 2013
- Prognostic Utility of Changes in N-Terminal Pro-Brain Natriuretic Peptide Combined with Sequential Organ Failure Assessment Scores in Patients with Acute Lung Injury/Acute Respiratory Distress Syndrome Concomitant with Septic ShockShock, 2011
- Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injuryPediatric Pulmonology, 2009
- Diagnostic and Prognostic Utility of Brain Natriuretic Peptide in Subjects Admitted to the ICU With Hypoxic Respiratory Failure Due to Noncardiogenic and Cardiogenic Pulmonary EdemaChest, 2007
- Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routineHeart, 2005
- Changes in Brain Natriuretic Peptide and Norepinephrine Over Time and Mortality and Morbidity in the Valsartan Heart Failure Trial (Val-HeFT)Circulation, 2003
- Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress SyndromeNew England Journal of Medicine, 2000
- Natriuretic peptides in detection of heart failureThe Lancet, 1998
- A new natriuretic peptide in porcine brainNature, 1988
- APACHE IICritical Care Medicine, 1985