Biological properties of garlic and garlic‐derived organosulfur compounds
Top Cited Papers
- 27 February 2009
- journal article
- review article
- Published by Wiley in Environmental and Molecular Mutagenesis
- Vol. 50 (3), 247-265
- https://doi.org/10.1002/em.20474
Abstract
Medicinal properties of garlic (Allium sativum) have been widely known and used since ancient times till the present. Garlic enhances immune functions and has antibacterial, antifungal and antivirus activities. It is known to prevent platelet aggregation, and to have hypotensive and cholesterol‐ and triglyceride‐lowering properties, although the latter features have been questioned. This review is focused on anticancer efficacy of Allium sativum, and attempts to explain the mechanisms of this action. Medicinal properties of garlic rely upon organosulfur compounds mostly derived from alliin. Organosulfur compounds originating from garlic inhibit carcinogen activation, boost phase 2 detoxifying processes, cause cell cycle arrest mostly in G2/M phase, stimulate the mitochondrial apoptotic pathway, increase acetylation of histones. Garlic‐derived sulfur compounds influence also gap‐junctional intercellular communication and participate in the development of multidrug resistance. This review presents also other little known aspects of molecular action of garlic‐derived compounds, like modulation of cellular redox state, involvement in signal transduction and post‐translational modification of proteins by sulfane sulfur or by formation of mixed disulfides (S‐thiolation reactions). Environ. Mol. Mutagen. 2009.Keywords
This publication has 129 references indexed in Scilit:
- Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compoundsCancer Letters, 2008
- Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/BakMolecular Cancer Therapeutics, 2007
- In vivo treatment by diallyl disulfide increases histone acetylation in rat colonocytesBiochemical and Biophysical Research Communications, 2007
- Antiproliferative effect of diallyl disulfide (DADS) on prostate cancer cell line LNCaPCell Biochemistry and Function, 2006
- Effects of dietary chemopreventive phytochemicals on P-glycoprotein functionBiochemical and Biophysical Research Communications, 2005
- Garlic as an antioxidant: the good, the bad and the uglyPhytotherapy Research, 2003
- Gap junctions: structure and function (Review)Molecular Membrane Biology, 2002
- Depressed p34cdc2kinase Activity and G2/M phase arrest induced by diallyl disulfide in HCT‐15 cellsNutrition and Cancer, 1998
- Allyl sulfides from garlic suppress thein vitroproliferation of human a549 lung tumor cellsNutrition and Cancer, 1997
- Novel Anti-Carcinogenic Activity of an Organosulfide from Garlic: Inhibition of H-RASOncogene Transformed Tumor Growthin Vivoby Diallyl Disulfide Is Associated with Inhibition of p21H-rasProcessingBiochemical and Biophysical Research Communications, 1996