Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease: Mechanisms and Therapeutic Implications
Top Cited Papers
Open Access
- 26 August 2019
- journal article
- review article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 16 (17), 3104
- https://doi.org/10.3390/ijerph16173104
Abstract
New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events.Keywords
This publication has 136 references indexed in Scilit:
- PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver DiseasePLOS ONE, 2013
- Additive relationship between serum fibroblast growth factor 21 level and coronary artery diseaseCardiovascular Diabetology, 2013
- Non-Alcoholic Fatty Liver Disease Is Associated with an Increased Incidence of Atrial Fibrillation in Patients with Type 2 DiabetesPLOS ONE, 2013
- Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 LociPLoS Genetics, 2011
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic TraitsPLoS Genetics, 2011
- Human oral, gut, and plaque microbiota in patients with atherosclerosisProceedings of the National Academy of Sciences of the United States of America, 2010
- Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver DiseaseThe New England Journal of Medicine, 2010
- Correlates and Heritability of Nonalcoholic Fatty Liver Disease in a Minority CohortObesity, 2009
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseNature Genetics, 2008
- Dietary Patterns and Risk of Mortality From Cardiovascular Disease, Cancer, and All Causes in a Prospective Cohort of WomenCirculation, 2008