Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum
Open Access
- 17 July 2013
- journal article
- Published by Springer Science and Business Media LLC in Malaria Journal
- Vol. 12 (1), 1-9
- https://doi.org/10.1186/1475-2875-12-249
Abstract
Plasmodium falciparum has repeatedly evolved resistance to first-line anti-malarial drugs, thwarting efforts to control and eliminate the disease and in some period of time this contributed largely to an increase in mortality. Here a mathematical model was developed to map the spatiotemporal trends in the distribution of mutations in the P. falciparum dihydropteroate synthetase (dhps) gene that confer resistance to the anti-malarial sulphadoxine, and are a useful marker for the combination of alleles in dhfr and dhps that is highly correlated with resistance to sulphadoxine-pyrimethamine (SP). The aim of this study was to present a proof of concept for spatiotemporal modelling of trends in anti-malarial drug resistance that can be applied to monitor trends in resistance to components of artemisinin combination therapy (ACT) or other anti-malarials, as they emerge or spread.Keywords
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