N6-methyladenosine–encoded epitranscriptomics
- 3 February 2016
- journal article
- Published by Springer Science and Business Media LLC in Nature Structural & Molecular Biology
- Vol. 23 (2), 98-102
- https://doi.org/10.1038/nsmb.3162
Abstract
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian m6A modification, which affects many different stages of the RNA life cycle.Keywords
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