D‐verapamil and L‐verapamil are equally effective in increasing vincristine accumulation in leukemic cells in vitro
- 15 February 1988
- journal article
- Published by Wiley in International Journal of Cancer
- Vol. 41 (2), 224-226
- https://doi.org/10.1002/ijc.2910410211
Abstract
Leukemic cells isolated from peripheral blood from 6 patients with chronic lymphocytic leukemia, immunocytoma and prolymphocytic leukemia were incubated with vincristine (10nM) with and without racemic verapamil and its L‐ and D‐ isomers (6.6 μM). Verapamil increased vincristine accumulation in all cells, the increase varying between 100 and 700%. Racemic verapamil and the L‐ and D‐isomer increased cellular vincristine accumulation to the same extent. The verapamil effect could not be reversed by increasing the calcium concentration in the incubation medium (final concentration 2.5–5.0mm). The results indicate that the mechanism behind the effect of verapamil on cellular accumulation of vincristine does not depend upon changes in calcium transport.Keywords
This publication has 7 references indexed in Scilit:
- Calcium-Antagonist DrugsNew England Journal of Medicine, 1985
- Decreased retention of vinca alkaloids in chronic lymphatic leukemia cells from refractory patientsCancer Chemotherapy and Pharmacology, 1985
- The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humansAmerican Heart Journal, 1985
- Restoration of doxorubicin responsiveness in doxorubicin-resistant P388 murine leukaemia cellsBritish Journal of Cancer, 1984
- Chemosensitizers counteracting acquired resistance to anthracyclines and vinca alkaloidsin vivo. A new treatment principleCancer Treatment Reviews, 1984
- The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1968