IL-6 predicts organ dysfunction and mortality in patients with multiple injuries
Open Access
- 1 January 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
- Vol. 17 (1), 49-7
- https://doi.org/10.1186/1757-7241-17-49
Abstract
Although therapeutic concepts of patients with major trauma have improved during recent years, organ dysfunction still remains a frequent complication during clinical course in intensive care units. It has previously been shown that cytokines are upregulated under stress conditions such as trauma or sepsis. However, it is still debatable if cytokines are adequate parameters to describe the current state of trauma patients. To elucidate the relevance of cytokines, we investigated if cytokines predict development of multiple organ dysfunction syndrome (MODS) or outcome. A total of 143 patients with an injury severity score ≥ 16, between 16 and 65 years, admitted to the Hannover Medical School Level 1 Trauma Center between January 1997 and December 2001 were prospectively included in this study. Marshall Score for MODS was calculated for at least 14 days and plasma levels of TNF-α, IL-1β, IL-6, IL-8 and IL-10 were measured. To determine the association between cytokine levels and development of MODS the Spearman rank correlation coefficient was calculated and logistic regression and analysis were performed. Patients with MODS had increased plasma levels of IL-6, IL-8 and IL-10. IL-6 predicted development of MODS with an overall accuracy of 84.7% (specificity: 98.3%, sensitivity: 16.7%). The threshold value for development of MODS was 761.7 pg/ml and 2176.0 pg/ml for mortality during the in patient time. We conclude that plasma IL-6 levels predict mortality and that they are a useful tool to identify patients who are at risk for development of MODS.Keywords
This publication has 38 references indexed in Scilit:
- Male Gender is Associated With Excessive IL-6 Expression Following Severe InjuryJournal Of Trauma-Injury Infection and Critical Care, 2008
- Epidemiology and Contemporary Patterns of Trauma Deaths: Changing Place, Similar Pace, Older FaceWorld Journal of Surgery, 2007
- INFLUENCE OF SEX AND AGE ON MODS AND CYTOKINES AFTER MULTIPLE INJURIESShock, 2007
- C-reactive protein is expressed and secreted by peripheral blood mononuclear cellsClinical and Experimental Immunology, 2006
- Changes in the Management of Femoral Shaft Fractures in Polytrauma Patients: From Early Total Care to Damage Control Orthopedic SurgeryJournal Of Trauma-Injury Infection and Critical Care, 2002
- Changes in blood lymphocyte populations after multiple traumaCritical Care Medicine, 1999
- Plasma tumor necrosis factor-α, its soluble receptors and interleukin-1β levels in critically burned patientsBurns, 1998
- Posttraumatic Inflammatory Response, Secondary Operations, and Late Multiple Organ FailureThe Journal of Trauma and Acute Care Surgery, 1996
- ELEVATED LEVELS OF SOLUBLE ICAM-1 CORRELATE WITH THE DEVELOPMENT OF MULTIPLE ORGAN FAILURE IN SEVERELY INJURED TRAUMA PATIENTSThe Journal of Trauma and Acute Care Surgery, 1994
- Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in SepsisSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1992